| Sac, n.m. | xiquipilli, matlaxiquipilli |
| Sacoche, n.f. | matlaxiquipilli |
| Saisir, v.t. | āna |
| Sale, adj. | catzāhuac, catzactic, catzactix, ahtlapactli |
| Salé, adj. | poyec |
| Saler, v.t. | poyelia |
| Saleté, n.f. | catzactiliztli, chichictli, tzōtl |
| Sali, adj. | chichicauhqui, chichicyoh |
| Salir, v.t. | catzāhua, catzactilia, chichicoa, chichictilia |
| Salive, n.f. | iztlactli |
| Saluer, v.t. | ciyāuhquetza, v.t. tē-., tlahpaloa, v.t. tē-. |
| Sandale, n.f. | cactli |
| Sang, n.m. | eztli |
| Sangle, n.f. | cuitlalpihcayōtl |
| Sanglot, n.m. | tziucnoliztli |
| Sangloter, v.i. | tziucnoa |
| Sans cesse | achchica |
| Santé n.f. | pāccāyeliztli |
| Sauce, n.f. | mōlli |
| Saut, n.m. | chololiztli |
| Sauter, v.i | choloa |
| (faire) Sauter | chichitōnia |
| Sauterelle, n.f. | chapolin, tzāhuanittzin |
| Sauver qqn. | māquīxtia |
| Saveur, n.f. | huēlicāyōtl |
| Savoir, v.t. | mati |
| Savon végétal | ahmōlli |
| Savoureux, adj. | ahhuiyāc, huēlic, huēlicāmachōni |
| Scandale, n.m. | neizahuiliztli |
| Scarabée, n.m. | pinacatl, temōlin, mayātl |
| Scorpion, n.m. | cōlōtl |
| Sec, adj. | huācqui |
| Sècher, devenir sec. | huāqui |
| Sècher qqch. | huātza |
| Sécheresse, n.f. | huāccāyōtl |
| Secouer, v.tr. | tzetzeloa, huihuixoa |
| Séduire v.tr. | xōchihuia, camanalhuia, yōlēhua |
| Seins, n.m.pl. | chīchihualli |
| Sel, n.m. | iztatl |
| Semence n.f. | achtli |
| Semer, v.t | chayāhua |
| Séparément, adv. | nōncuah |
| Sept | chicōme |
| Serpent, n.m. | cōātl |
| Serrure, n.f. | tlatzacualōni |
| Servante, n.f. | tepi |
| Servir, être au service de qqn. | aachti |
| Seul | cēl ou iyoh |
| Sevrer un enfant | chīchihualcāhualtia |
| Siège, n.m. | icpalli |
| Sifflet, n.m. | chīchtli |
| (faire) Signe | chihchihcopi |
| Silence, n.m. | necāhualiztli |
| Singe, n.m. | ozomahtli |
| Sinueux, adj. | chīchihcōltic, chihchihcōltic |
| Soeur aînée, n.f. | tepi |
| Soif, n.f. | āmiquiliztli |
| Sol, n.m. | tlālpantli |
| Solliciter, v.t. | ihtlani, ihtlanilia, v.bitrans., |
| Sommeil, n.m. | cochiztli ou cochiliztli |
| Sommet, n.m. | tzonyôtl |
| Sommet d'une montagne | tepēticpac, locatif |
| Son, n.m. | caquiztiliztli, caquiztli |
| Sonnailles, n.f.pl. | ayacachtli |
| Songe, n.m. | tēmictli, cochihtlehualli, iztlacatemictli |
| Soporifique, adj. | cochīhuani |
| Sorcellerie, n.f. | chīchyōtl |
| Sortir, v.i. | quīza |
| Sot, n.m. | cohcotoc |
| Souffle, n.m. | ihīyōtl |
| Souffler, v.i. | pītza |
| Souffrir, v.t. | pāccāyōhuia |
| Souffrir, v.i. | ihīyōhuia, chichinaca |
| Souffrir beaucoup | chīchichīna, chīchichinaca |
| Soulever quelque chose | ahcocui |
| Soupir, n.m. | tziucnoliztli |
| Soupirer, v.i. | tziucnoa, ēlcihcihui |
| Source, n.f. | āmēyalli, āpatzquitl |
| Sourd, n.m. | nacatzatzatl |
| Souris, n.f. | quimichin, calquimichin |
| Souterrain, n.m. | tlāloztōtl |
| (se) Souvenir de | ilnāmiqui |
| Souvenir qu'on a de quelqu'un. | tēilnāmiquiliztli |
| Souvent | achca ou achcān, achchica |
| Spectateurs, n.m.pl. | tlahtlattaqueh |
| Sperme,, n.m. | oquichxinachyōtl |
| Spongieux, adj. | zōnectic |
| Statue, n.f. | tecuacuilli |
| Submerger, v.t. | ācalaquia |
| Subvenir, v.t. | chīhua, réfl. |
| Sucer, v.t. | chichīna |
| Sucré | tzopēlic |
| Sueur, n.f. | tzōtl |
| Suffocation, n.f. | ihīyōcāhualiztli |
| Sulfate de cuivre | tlāliyac |
| Supplier, v.t. | tlahtlauhtia |
| Supporter v.t. | pāccāyōhuia |
| Surface, n.f. | īxtli |
| Surpasser, v.t. | panāhuia |
| Surveiller, v.t. | pachihuia, v.bitrans. motē-. ou motla-. |
| Survenir, v.i. | huālahci |
| Suspendre, v.t. | piloa |
| Suspicion, n.f. | chāhualiztli |